Curaleaf sits on Main Street in Oxford, just off Route 395 in south-central Worcester County — and carries the distinction of being the first adult-use recreational cannabis dispensary to open in Massachusetts, launching in November 2019 after operating as a medical facility since 2018. The Oxford location remains one of Curaleaf’s flagship Massachusetts stores, serving shoppers from Oxford, Webster, Charlton, Sturbridge, Dudley, and the towns along the Route 395 and Route 20 corridor. The menu covers flower, pre-rolls, vaporizer cartridges, edibles, concentrates, tinctures, and topicals under Curaleaf’s house brand lineup — Curaleaf, Grassroots, and Select — alongside a rotating selection of Massachusetts partner brands. Online ordering is available for pickup, and the store is known for friendly, knowledgeable staff and consistently competitive pricing. Curaleaf Oxford suits recreational cannabis shoppers throughout southern Worcester County who want one of the state’s most experienced dispensaries with a proven track record and convenient Route 395 access.

Phone: (508) 731-0100 Address: 425 Main St, Ste B, Oxford, MA 01540 Hours: Mon–Sat 9:00 AM–8:00 PM | Sun 9:00 AM–6:00 PM Payment: Cash; debit Nearby neighborhoods served: Oxford, Webster, Charlton, Sturbridge, Dudley, Auburn, Worcester County Last verified: May 2026 Notes: Main St near Route 395; first adult-use recreational dispensary in Massachusetts (est. Nov. 2019; medical from 2018); multi-state chain (Curaleaf); Curaleaf, Grassroots, Select house brands; online pre-ordering; editor verify Google rating; recreational (medical Yelp listing CLOSED — editor verify current medical status) Website: curaleaf.com