Dispensary 33 at 5001 N. Clark Street in Andersonville made history when it opened in December 2015 as Chicago’s first licensed cannabis dispensary, and it has never stopped accumulating firsts. On January 1, 2020, when Illinois recreational sales went live at midnight, the first legal recreational cannabis purchase in Illinois history was made right here, at Clark and Argyle, by a West Loop resident who walked in before 6 AM and bought an eighth of Motorbreath OG. In 2025, Dispensary 33 and its partner Spark’d became the first fully employee-owned cannabis stores in Illinois — a structure that ties the store’s success directly to the people who run it every day. High Times called it one of the best cannabis dispensaries in America and Curbed named it one of the ten most high-design marijuana dispensaries in the country, citing wide windows, white brick, hexagonal display cases, and line-drawn cannabis murals that give the space the feel of a dedicated museum to the plant. Every product on the D33 menu is researched and tested by staff before it reaches the floor, and all products are displayed for customers to personally examine — a policy that reflects how seriously the store takes the idea of an informed purchase. The Cannabis Compassion Program donates one percent of all medical cannabis sales to patients in financial need, with up to six months of free cannabis assistance available for those who qualify. Online preorder through the D33 website keeps visits fast and touch-free, and the D33 Rewards program tracks purchases toward discounts and perks. The Argyle Red Line stop is less than a block away. Dispensary 33 Andersonville is the right fit for recreational adults and medical patients across Andersonville, Edgewater, Uptown, Ravenswood, Rogers Park, and the broader far north side who want Chicago’s original dispensary — employee-owned, independently curated, nationally recognized, and operating at Clark and Argyle as a neighborhood anchor since 2015.

Phone: (312) 620-3333 Address: 5001 N Clark St, Chicago, IL 60640 Hours: Daily 9:00 AM–9:00 PM Payment: Cash; ATM on-site Nearby neighborhoods served: Andersonville IL, Edgewater IL, Uptown IL, Ravenswood IL, Rogers Park IL, Lincoln Square IL, Far North Side Chicago, Cook County IL Last verified: May 2026 Notes: 5001 N Clark St (Clark & Argyle), Chicago IL 60640; Andersonville neighborhood; Red Line to Argyle; Chicago’s first cannabis dispensary (opened December 2015); site of Illinois’ first legal recreational purchase (Jan 1, 2020); employee-owned (2025, with Spark’d); medical + recreational (21+); curated test-before-sell product philosophy; Cannabis Compassion Program (1% of medical sales to patients in need; up to 6 months free cannabis assistance); online preorder; D33 Rewards; ADA accessible; cash + ATM; license 284000012-AUDO; High Times “Best Cannabis Dispensaries in America”; Curbed “10 Most High-Design Marijuana Dispensaries in the U.S.”; Google rating not confirmed; medical and recreational Website: dispensary33.com