First State Compassion is a medical cannabis dispensary in Lewes, Delaware, now operating as Thrive Dispensary Lewes. The store is at 12000 Old Vine Boulevard, Unit 102, Lewes, Delaware 19958, near the Route 1 retail corridor. It is a licensed Delaware dispensary serving registered medical marijuana patients.

First State Compassion was Delaware’s first licensed medical cannabis operator, and its Lewes store opened in 2017 as the company’s second location. The company also runs a dispensary and cultivation site in Wilmington, and the Lewes store has since become part of Thrive Dispensaries.

The dispensary carries flower, pre-rolls, vape cartridges, concentrates, edibles, tinctures, and topicals from its own cultivation and other Delaware producers. It offers walk-in service, curbside pickup, and daily delivery, and accepts out-of-state medical marijuana cards. Payment options include debit cards and digital methods such as Pay By Bank, Venmo, and PayPal.

The Lewes store is open Monday through Saturday from 9:00 AM to 8:00 PM and Sunday from noon to 6:00 PM. Old Vine Boulevard sits near the Tanger Outlets off Route 1, between Lewes and Rehoboth Beach in Sussex County. It serves patients across coastal Sussex County, including Lewes, Rehoboth Beach, and Milton.

Who can shop at First State Compassion in Lewes?

Registered medical marijuana patients, including those with valid out-of-state medical cards. Delaware requires a state-issued medical marijuana card to purchase.

Does the Lewes dispensary offer delivery and pickup?

Yes. The store offers walk-in service, curbside pickup, and daily delivery across the area.

Is this the same store as Thrive Dispensary Lewes?

Yes. The Lewes First State Compassion dispensary now operates under the Thrive Dispensaries brand at the same Old Vine Boulevard location.

First State Compassion — Lewes Phone: (302) 281-4888 Address: 12000 Old Vine Blvd, Unit 102, Lewes, DE 19958 Hours: Mon–Sat 9:00 AM–8:00 PM; Sun 12:00–6:00 PM Products: Flower, pre-rolls, vape cartridges, concentrates, edibles, tinctures, and topicals Services: Walk-ins, curbside pickup, daily delivery; accepts out-of-state medical marijuana cards; loyalty program Payment: Debit cards; digital payment via Pay By Bank, Venmo, and PayPal Nearby areas served: Lewes DE, Rehoboth Beach DE, Milton DE, Sussex County DE Last verified: June 2026 Notes: Licensed Delaware medical cannabis dispensary; originally First State Compassion (Delaware’s first licensed cannabis operator), Lewes store opened 2017; now operating under the Thrive Dispensaries brand; sister location in Wilmington; near the Tanger Outlets off Route 1.  Website: firststatecompassion.com