Ascend Cannabis Dispensary at 1014 Eastport Plaza Drive in Collinsville is Ascend Wellness Holdings’ flagship Illinois location, sitting just off the I-55/70 interchange at Exit 10 in Madison County’s Metro East corridor — a position that makes it one of the most conveniently accessible dispensaries for St. Louis-area residents crossing into Illinois for legal cannabis. The store operates in the former Illinois Supply & Provisions building next to the Illinois State Police headquarters, between the DoubleTree Hotel and the state police complex on Eastport Plaza Drive. The location puts customers within roughly ten minutes of the iconic World’s Largest Catsup Bottle on Collinsville’s Belt Line Road and a short drive from the Cahokia Mounds State Historic Site, a UNESCO World Heritage Site. Both medical patients and recreational customers 21 and older are served under Illinois license 284000025-AUDO. The product menu spans flower, vapes, concentrates, edibles, and topicals, with Ascend’s house brands — Ozone, Simply Herb, High Wired, Effin’ Edibles, and Honor Roll — prominently featured. Payment runs through cash, debit, or Ascend Pay direct bank transfer; three ATMs are on-site. Online ordering is available for pickup or curbside. The Ascenders Club loyalty program earns one point per dollar spent pre-tax, with double value on select Ascend house brands at redemption. On-site parking is available behind the building at 2 Executive Drive, with additional overflow parking at the adjacent Gateway Fun Park and a free shuttle running between the two lots. Medical card process guidance is available in-store. A 4.5-star Google rating from more than 3,700 reviews — one of the highest review volumes of any dispensary in the greater St. Louis market on either side of the river — reflects the steady draw of a location that has served this corridor since the early days of Illinois cannabis under its previous name. Ascend Collinsville suits recreational adults and medical patients across Collinsville, Belleville, O’Fallon, Shiloh, Fairview Heights, Maryville, Troy, Edwardsville, and the broader Metro East and St. Louis bi-state region who want a high-volume, full-service dispensary at a major interstate interchange.

Phone: (312) 535-3905 Address: 1014 Eastport Plaza Drive, Collinsville, IL 62234 Hours: Daily 8:00 AM–9:00 PM Payment: Cash; debit; Ascend Pay; ATM on-site (three ATMs) Nearby neighborhoods served: Collinsville IL, Belleville IL, O’Fallon IL, Fairview Heights IL, Shiloh IL, Maryville IL, Troy IL, Edwardsville IL, Madison County IL, Metro East Illinois, St. Louis MO area Last verified: May 2026 Notes: 1014 Eastport Plaza Drive, Collinsville IL 62234; Madison County; Ascend Wellness Holdings (AWH) — formerly Illinois Supply & Provisions (illinoissandp.com); medical + recreational (21+); IL license 284000025-AUDO; AWH flagship IL location; off I-55/70 Exit 10; cash + debit + Ascend Pay + three ATMs on-site; online ordering + curbside pickup; Ascenders Club loyalty; house brands: Ozone, Simply Herb, High Wired, Effin’ Edibles, Honor Roll; on-site parking (2 Executive Dr) + Gateway Fun Park overflow + free shuttle; near World’s Largest Catsup Bottle + Cahokia Mounds + Illinois State Police HQ; medical card guidance available on-site; Google 4.5★ (3,701 reviews); medical and recreational Website: letsascend.com