AYR Cannabis Dispensary runs a medical cannabis dispensary on South U.S. Highway 1 in Port St. Lucie. The store sits at 10941 S U.S. Highway 1, Port St. Lucie, Florida 34952. It operates as a licensed Florida Medical Marijuana Treatment Center. The dispensary serves St. Lucie County, including Port St. Lucie, Stuart, and Hobe Sound.

AYR Wellness, a national cannabis operator, runs the store. Shelves carry the house line kynd, plus partner brands Camino and Petra. The menu covers flower, pre-rolls, vape cartridges, concentrates, edibles, capsules, tinctures, and topicals. The store takes cash, debit, and CanPay, with an ATM on site.

First-time clients get a discount, and AYR runs veteran, senior, and birthday offers. Patients can order online for in-store pickup. The store opens 9:00 AM to 8:30 PM Monday through Saturday and 10:00 AM to 8:00 PM Sunday.

This stretch of U.S. 1 runs through southern Port St. Lucie near the Martin County line. The store sits a short drive from Stuart and the Jensen Beach area. It draws patients from Port St. Lucie, Stuart, and Hobe Sound.

Who is AYR Cannabis Dispensary Port St. Lucie for?

AYR Cannabis Dispensary Port St. Lucie is a medical cannabis dispensary for registered Florida patients. It serves St. Lucie County, from Port St. Lucie to Stuart and Hobe Sound.

Do I need a Florida medical card to shop here?

Yes. Purchases require an active Florida Medical Marijuana Card. Florida is a medical-only state and does not accept out-of-state cards.

Can I order online for pickup at AYR Port St. Lucie?

Yes. Florida patients can order online for in-store pickup, then browse the rest in person.

AYR Cannabis Dispensary (formerly Liberty Health Sciences) Phone: (772) 249-4199 Address: 10941 S US Highway 1, Port St. Lucie, FL 34952 Hours: Mon–Sat 9:00 AM–8:30 PM; Sun 10:00 AM–8:00 PM Payment: Cash, debit, CanPay, ATM on-site Nearby neighborhoods served: Port St. Lucie FL, Stuart FL, Jensen Beach FL, Hobe Sound FL, St. Lucie County FL Last verified: May 2026 Notes: Licensed Florida Medical Marijuana Treatment Center; operated by AYR Wellness; 10941 S US Highway 1 — U.S. 1 in southern Port St. Lucie near the Martin County line; house line kynd plus partner brands Camino and Petra; flower + pre-rolls + vape cartridges + concentrates + edibles + capsules + tinctures + topicals; cash + debit + CanPay + ATM; first-time client discount, veteran, senior, and birthday offers; online ordering for in-store pickup open 7 days. Website: ayrdispensaries.com/florida/port-st-lucie