SeaWeed Co. at 185 Running Hill Road holds a significant place in Maine cannabis history — it was the first recreational cannabis retail store to open in the state when it launched in 2020, followed by the Portland location becoming the first recreational storefront in that city in 2021. The South Portland store sits in the Maine Mall area directly across from Target, near the Portland International Jetport and I-295, with a large parking lot that makes it a straightforward stop for commuters, travelers, and mall-area shoppers across Cumberland County. The award-winning interior design — described as clean, earthy, and rooted in Maine’s coastal aesthetic — has drawn recognition beyond the product itself, making the store a destination rather than just a transaction point. SeaWeed Co. is Maine-owned and operated, crafting in-house cannabis products and specializing particularly in live resin extracts alongside a full menu of flower, pre-rolls, edibles, concentrates, beverages, CBD, and locally crafted accessories, merchandise, and original Maine art. The mission is education-first: staff are trained to personalize recommendations based on experience level, intended effect, and dosing preferences, with the philosophy that cannabis effects are highly individual and best experienced with guidance. Delivery is available through seaweedmaine.com for the broader Portland area. This location is adult-use recreational only — no medical card required — with debit accepted at the counter. SeaWeed Co. South Portland suits recreational adults 21-plus across South Portland, Portland, Scarborough, Cape Elizabeth, and the broader Maine Mall corridor who want Maine’s original licensed recreational dispensary with an award-winning store experience, live resin expertise, and Jetport-adjacent convenience.

Phone: (207) 819-4114 Address: 185 Running Hill Rd, South Portland, ME 04106 Hours: Mon–Sat 10:00 AM–8:00 PM | Sun 10:00 AM–6:00 PM Payment: Debit; cash (ATM may be on-site; call to confirm) Nearby neighborhoods served: South Portland ME, Portland ME, Scarborough ME, Cape Elizabeth ME, Maine Mall area, Cumberland County ME Last verified: May 2026 Notes: 185 Running Hill Rd, South Portland; near Maine Mall (across from Target); near Portland Jetport (PWM) and I-295; large parking lot; first recreational cannabis retail store in Maine (2020); first Portland rec storefront (2021); Maine-owned; 2 locations (South Portland + Portland 23 Marginal Way Suite 7); specializes in live resin extracts; in-house products; local art + accessories; delivery available (seaweedmaine.com); adult-use only (no medical card); debit accepted; award-winning store design; license AMS135; Google rating not confirmed; Yelp March 2026 (18 reviews); Weedmaps active; recreational (21+) Website: seaweedmaine.com