Trulieve at 11291 East Colonial Drive in Orlando, Florida, operates as a Florida-licensed Medical Marijuana Treatment Center (MMTC) in the 32817 zip code on State Road 50 — East Colonial Drive — near the intersection of Rouse Lake Road and within the Waterford Lakes corridor of east Orlando, one of the highest-density retail and residential zones along the Orange-Seminole County boundary. The East Colonial Drive location is one of four Trulieve dispensaries in the greater Orlando metropolitan area, serving a distinct east Orlando patient base including the Waterford Lakes, Alafaya, and UCF-adjacent communities that fall east of the primary downtown and Millenia corridors. Waterford Lakes Town Center, one of the largest open-air shopping destinations in east Orlando, sits in the immediate trade area, and Orlando Health is approximately ten minutes from this location. Trulieve carries the full in-house brand portfolio across flower, vapes, edibles, tinctures, topicals, concentrates, and RSO with online ordering available for in-store pickup. This location operates on a slightly different schedule from some Florida Trulieve dispensaries — closing at 8:30 PM Monday through Saturday rather than 8:45 PM — with Sunday hours beginning at 11:00 AM. Patient volume at this location tends to peak on weekends; weekday morning visits between 10:00 AM and noon typically offer the shortest wait times per the dispensary’s own guidance. Home delivery is available from this location with a $50 minimum order, a $15 fee below $100, and free delivery for qualifying patients 65 and older.

Does Trulieve Orlando Colonial Drive require a Florida medical marijuana card? Yes — Trulieve operates as a Florida MMTC under OMMU licensing, and a valid Florida Medical Marijuana Card is required for all purchases.

Does Trulieve Orlando Colonial Drive accept out-of-state medical marijuana cards? No — Florida’s MMTC program does not provide reciprocity for out-of-state medical cards.

Trulieve Phone: (407) 512-9707 Address: 11291 E Colonial Dr, Orlando, FL 32817 Hours: Mon–Sat 9:00 AM–8:30 PM | Sun 11:00 AM–8:00 PM Payment: Cash, CanPay, ATM on-site (confirm) Nearby neighborhoods served: Orlando FL, east Orlando FL, Waterford Lakes FL, Alafaya FL, UCF area FL, Oviedo FL, east Orange County FL Last verified: March 2026 Notes: Florida MMTC; 11291 E Colonial Dr (State Road 50) — near Rouse Lake Rd + Waterford Lakes Town Center; ~10 min from Orlando Health; one of four Trulieve Orlando-area locations; flower + vapes + edibles + tinctures + topicals + concentrates + RSO; Cash + CanPay + ATM; online ordering + pickup; delivery $50 min; $15 fee below $100; free delivery patients 65+; weekends busiest — shortest wait weekday mornings 10AM–noon; Sun opens 11:00 AM; open 7 days. Website: trulieve.com